Phenibut For Treating Stress, Anxiety, and Depression

By: Jadon Webb, MD, PhD

With all the news about the state of the economy, and trying to reckon with years of dramatic changes from COVID, stress continues to plague us at home, school, and work. High stress also increases the risk of generalized anxiety disorder, major depression, PTSD, and other illnesses. 

There are a number of effective, prescribed treatments for conditions such as depression and generalized anxiety. Many of our clients also inquire about using over the counter, natural, and other alternative drugs and supplements. 

One of the most popular alternative drugs being used is phenibut. Phenibut is a synthetic drug that was developed in Russia, and is similar in chemical structure to the neurotransmitter GABA. It acts most similarly to the prescription drug baclofen, which is used in the United States. Phenibut is in a legal gray area in the US, and was technically legal to possess as of this writing, but has major restrictions on being manufactured and sold. 

Phenibut is often used for insomnia and anxiety. On the internet, many users give it high marks for efficacy and tolerability. It often produces a feeling of reduced anxiety, while sometimes even increasing focus and attention. But that said, we urge great caution as it is a powerful drug that can cause dependence and can have serious side effects if misused.  
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If you are using phenibut or interested in it, definitely let your provider know! It is an important substance that, for better or worse, is playing a big role in how our community is addressing a wave of stress and anxiety.

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